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. 2017 Aug 15;18:268. doi: 10.1186/s12882-017-0686-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Effect of tolvaptan 60 mg during and after NO inhibition on GFR (⁵¹ Cr-EDTA-clearance) (a), UO (b), C_H2O (c) and u-AQP2 (d) in ADPKD. Data are given as mean ± SEM or medians with 25th and 75th percentiles. General linear model (GLM) with repeated measures was performed for comparison within and between groups. Paired t-test was used for comparison between tolvaptan and placebo treatment during L-NMMA infusion period (90–150 min) and post infusion period (150–210 min)