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. 2017 Jul 4;117(4):503–512. doi: 10.1038/bjc.2017.197

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Copyright © 2017 The Author(s)

This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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High TOPK expression correlates with poor outcomes in prostate cancer patients.(A) HCT116 cells were transfected with siRNA and irradiated (4 Gy). Metaphases were collected at 24, 48 and 72 h following irradiation and scored for chromosomal aberrations, with 40 nuclei analysed in each group. Images of representative metaphases include examples of typical errors detected (insets). Arrows indicate chromosomal aberrations. (B) Average number of errors per metaphase from three independent experiments *P<0.05 and **P<0.01. (C) Representative photomicrographs taken following immunohistochemistry staining with an anti-TOPK antibody, showing non-staining in disease-free prostate epithelium and strong nuclear and cytoplasmic TOPK expression in prostatic carcinoma. (D) Kaplan–Meier analysis of TOPK expression and overall survival, and any recurrence in prostate cancer patients following radical radiotherapy (n=128). P-value from univariate analysis.