Figure 2.

Efficacy of cholesterol transport inhibitors on xenografted melanoma tumour development. (A) bar graph representing the effect of oral administration of desipramine, nortriptyline and perphenazine on xenografted UACC 903 melanoma tumour growth at day 22; (B) H&E stained tumour sections showing vacuolisation of tumours harvested from animals treated with perphenazine; (C) bar graph showing average number of mitotic figures identified in H&E stained sections of tumours harvested from perphenazine or vehicle-treated mice; (D–H) growth kinetics or tumour weights of UACC 903, 1205 Lu and A2058 xenografted tumours following oral administration of fluphenazine (25 mg kg⁻¹) or perphenazine (50 mg kg⁻¹). Image (inset in D) showing UACC 903 tumours harvested at the end of the experiment. (E and H) bar graphs showing tumour weight percentages compared to vehicle-treated animals, harvested from UACC 903 and A2058 xenografts, respectively; (I) bar graph showing the weight loss of mice with UACC 903 xenografts 2 days after drug treatments. *P < 0.05; **P < 0.01; ***P < 0.001.