Figure 3.

Liposomal administration of perphenazine enhanced therapeutic activity while decreasing sedative side effects. (A) bar graph showing activity of mice following oral or intravenous liposomal administration of perphenazine; (B) sleep behaviour of mice treated with perphenazine; (C) bar graph showing body weight change in Swiss Webster mice following oral or intravenous liposomal administration of perphenazine (DA: Drug administration); (D) efficacy of liposomal perphenazine on cultured UACC 903 melanoma cells survival; (E and G) growth kinetics of UACC 903 and 1205 Lu xenografted tumours following intravenous administration of 15 mg kg⁻¹ liposomal perphenazine. Inserts in each graph show average mice weight during the treatment period; (F) distribution of tumour weights harvested from mice treated with empty or perphenazine encapsulated liposomes; (H) H&E stained vital organ sections of mice treated with empty or perphenazine encapsulated liposomes. ***P < 0.001.