Table 1. Characteristics of tumours and patients with TUBR.
|
TERT promoter mutation |
||||
|---|---|---|---|---|
| Variables | n | Mutated (n=280) | Wild type (n=68) | P-valuea |
|
Age at diagnosis (years) | ||||
| Median (range) | 348 | 74 (34–97) | 68 (27–95) | 0.0017 |
|
Sex | ||||
| Female | 52 | 39 (75.0%) | 13 (25.0%) | 0.2816 |
| Male | 296 | 241 (81.4%) | 55 (18.6%) | |
|
Tumour stage | ||||
| pTa | 199 | 158 (79.4%) | 41 (21.6%) | 0.4979 |
| pT1 | 76 | 59 (77.6%) | 17 (22.4%) | |
| >pT1 | 61 | 52 (85.2%) | 9 (14.8%) | |
| pTis concomitant | 12 | 11 (91.7%) | 1 (8.3%) | |
|
Histological grade | ||||
| Low-grade | 144 | 107 (74.3%) | 37 (25.7%) | 0.0150 |
| High-grade | 204 | 173 (84.8%) | 31 (15.2%) | |
|
Cytology | ||||
| Negative | 115 | 84 (73.0%) | 31 (27.0%) | 0.1103 |
| AUC-USb | 19 | 17 (89.5%) | 2 (10.5%) | |
| Low-grade | 97 | 79 (81.4%) | 18 (18.6%) | |
| AUC-Hb | 8 | 6 (75.0%) | 2 (25.0%) | |
| High-grade | 109 | 94 (86.2%) | 15 (13.8%) | |
Abbreviations: AUC-H=Atypical urothelial cells of high grade; AUC-US=atypical urothelial cells of undetermined significance; TERT=telomerase reverse transcriptase.
a
P-values correspond to χ2-test or Mann-Whitney test (age).
b
Atypical urothelial cells of undetermined significance (AUC-US) or cannot exclude high grade (AUC-H).