Fig. 1.

Rapid evolution among 2310003L06Rik orthologues. a Nucleotide conservation is low across placental mammals, and the locus is not aligned with non-mammalian species. The mouse gene is incompletely predicted in Ensembl, and absent from other databases such as RefSeq and CCDS. b Rapid evolution of mammalian 2310003L06Rik orthologues. Open reading frames (shown in grey) are of highly variable length (amino acid numbers shown on the right) across mammalian species (phylogeny shown on left, not to scale). Human, chimpanzee and macaque genomes contain nucleotide substitutions that truncate the open-reading frame (“!”; pseudogene indicated in black). Deletions in the squirrel (Spermophilus tridecemlineatus) orthologue, relative to the dog, are indicated by “Δ”, and repeats in the dog sequence are shown by “R”. Aligned protein sequences are indicated by dotted blue and brown lines. There is no significant sequence similarity evident between mouse and opossum (Monodelphis domestica) orthologues (blastp E > 0.2). d _N /d _S is explained in the legend to Fig. 2