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. 2017 Aug 16;15:71. doi: 10.1186/s12915-017-0411-5

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© Ponting et al. 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5. — Protein-coding sequence turns over very slowly but is a minority of all constrained sequence; functional non-coding sequence turns over rapidly and contributes most to constrained sequence. Circle areas reflect proportions of annotations that are constrained (~8% for the mammalian genome); annotations are not mutually exclusive. Protein-coding sequence half-life is approximately the age of bilateral animals, and the half-lives of functional non-coding sequence are approximately the age of the radiation of placental mammals [91–93]. Further details of the data and the evolutionary model are provided in [44]