Table 1.

Baseline patient characteristics of the two RA cohorts

	RA1 (n = 373)	RA2 (n = 114)
Female, n (%)	254 (68.1)	72 (63.2)
RF IgM positivity, n (%)	225 (60.3)	109 (95.6)
CCP2 IgG positivity, n (%)	217 (58.2)	114 (100)
Anti-CarP IgG positivity, n (%)	182 (49.2)	114 (100)
“Ever” smokers, n (%)	160 (42.9)	75 (65.8)
Age (years), mean (SD)	57.2 (15.8)	54.5 (12.0)

anti-CarP anti-carbamylated protein, Ig immunoglobulin, RA rheumatoid arthritis, RA1 discovery cohort, RA2 replication cohort, RF rheumatoid factor, SD standard deviation