Table 3.
Associations of anti-carbamylated protein antibody isotypes and IgG subclasses with baseline characteristics
| Isotypes | IgG– (n = 190) | IgG + (n = 182) | p | IgA– (n = 221) | IgA + (n = 152) | p | IgM– (n = 312) | IgM + (n = 61) | p | |||
| ESR, mm/h | 0.676 | 0.157 | 0.216 | |||||||||
| Mean ± SD Median (IQR) | 41.2 ± 25.3 37.0 (33.3) | 42.9 ± 26.8 37.0 (44.5) | 40.4 ± 25.7 34.5 (33.0) | 44.2 ± 26.4 39.0 (43.0) | 41.2 ± 25.8 37.0 (35.0) | 45.7 ± 26.8 44.0 (45.0) | ||||||
| CRP, mg/L | 0.694 | 0.039 | 0.092 | |||||||||
| Mean ± SD Median (IQR) | 32.0 ± 35.7 19.0 (34.0) | 33.3 ± 35.4 19.5 (36.3) | 28.9 ± 33.3 17.0 (28.8) | 38.0 ± 38.0 23.0 (48.0) | 29.9 ± 31.8 18.0 (31.0) | 46.0 ± 48.3 23.5 (59.8) | ||||||
| IgG subclasses | IgG1– (n = 33) | IgG1 + (n = 149) | p | IgG2– (n = 100) | IgG2 + (n = 82) | p | IgG3– (n = 157) | IgG3 + (n = 25) | p | IgG4– (n = 98) | IgG4 + (n = 84) | p |
| ESR, mm/h | 0.176 | 0.156 | 0.323 | <0.001* | ||||||||
| Mean ± SD Median (IQR) | 36.8 ± 24.2 32.0 (26.0) | 44.1 ± 27.3 37.0 (46.0) | 40.4 ± 26.3 34.0 (39.0) | 45.7 ± 27.4 44.5 (46.3) | 42.1 ± 26.9 34.5 (45.0) | 47.0 ± 26.6 51.0 (45.0) | 35.3 ± 23.2 30.0 (29.3) | 51.4 ± 28.3 49.0 (45.0) | ||||
| CRP, mg/L | 0.637 | 0.023 | 0.107 | 0.003* | ||||||||
| Mean ± SD Median (IQR) | 27.5 ± 26.1 20.0 (30.0) | 34.7 ± 37.2 19.5 (39.3) | 29.0 ± 33.1 17.5 (31.8) | 38.7 ± 37.7 26.0 (41.0) | 31.1 ± 33.4 18.0 (33.5) | 47.5 ± 44.8 32.0 (58.5) | 25.3 ± 27.2 16.0 (28.0) | 42.1 ± 41.1 28.0 (52.0) | ||||
Mann-Whitney U test to calculate P values for baseline parameters (ESR and CRP level)
IgG subclass analysis was performed in anti-carbamylated protein IgG-positive patients
Bold indicates a significant difference
* Remained significant after Holm-Bonferroni correction
Holm-Bonferroni correction was performed for independent analyses in whole cohort
CRP C-reactive protein, ESR erythrocyte sedimentation rate, Ig immunoglobulin, IQR interquartile range, SD standard deviation