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. 2017 Aug 15;16:137. doi: 10.1186/s12943-017-0707-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a. Mechanisms associated with the participation of neutrophils in the oncogenic process. Neutrophils are involved in various oncogenic processes such as tumor initiation, growth and proliferation, dissemination to other tissues, and formation of new blood vessels in the tumor. b. Therapeutic strategies to inhibit the oncogenic effect of neutrophils at different levels. Different compounds have been developed to target factors produced by the tumor and also to receptors present in neutrophils that favor the migration of neutrophils to the tumoral areas