Table 2.
Drug | Mechanism of action | Study number | Clinical stage | Indication | Alone or in combination |
---|---|---|---|---|---|
Reparixin | Reparixin Noncompetitive allosteric inhibitor of CXCR1 and CXCR2 chemokine. |
NCT02001974 | I | Metastatic Breast Cancer | Paclitaxel + Reparixin |
Reparixin | Reparixin Noncompetitive allosteric inhibitor of CXCR1 and CXCR2 chemokine |
NCT01861054 | II | Metastatic Breast Cancer | Alone |
Reparixin | Reparixin Noncompetitive allosteric inhibitor of CXCR1 and CXCR2 chemokine |
NCT02370238 | II | Metastatic Breast Cancer | Paclitaxel in Combination With Reparixin or Placebo |