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DLTs according to dose levels
| Dose level | Number of Assessable patients | Bevacizumab (Q2W) |
Pazopanib (Q.D) | Number of DLT |
|---|---|---|---|---|
| DL1 | 9 | 7.5 mg/kg | 400 mg | No DLT |
| DL1 Confirmatory Cohort | 6 | 3 DLT:- 2 grade 3 MAHAb | ||
| - 1 grade 3 ALT/AST | ||||
| DL2 | 10a | 7.5 mg/kg | 600 mg | 5 DLT:- 2 grade 3 ALT/ASTc |
| - 1 grade 3 pulmonary embolismc | ||||
| - 2 grade 3 MAHAc |
a1 patient dropped out for non-authorized dose reduction at week 5
bMAHA: Microangiopathic & hemolytic anemia
coccurred in one nephrectomized patient
