Table 3.
Adverse events (all grades, occurring in >10% of patients). Total number of patients N = 25
| Grade | ||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | All | ||
| N | N | N | N | N | % | |
| Fatigue | 6 | 6 | 1 | 0 | 13 | 52.0 |
| Hypertension | 4 | 6 | 2 | 0 | 12 | 48.0 |
| Anorexia | 8 | 3 | 0 | 0 | 11 | 44.0 |
| Nausea | 11 | 0 | 0 | 0 | 11 | 44.0 |
| Asthenia | 6 | 4 | 0 | 0 | 10 | 40.0 |
| Diarrhea | 8 | 1 | 1 | 0 | 10 | 40.0 |
| Dysphonia | 10 | 0 | 0 | 0 | 10 | 40.0 |
| Vomiting | 7 | 2 | 1 | 0 | 10 | 40.0 |
| Thrombocytopenia | 3 | 2 | 3 | 0 | 8 | 32.0 |
| Headache | 6 | 0 | 0 | 0 | 6 | 24.0 |
| Abdominal pain | 2 | 2 | 2 | 0 | 6 | 24.0 |
| Dysgeusia | 4 | 2 | 0 | 0 | 6 | 24.0 |
| Myalgia | 5 | 1 | 0 | 0 | 6 | 24.0 |
| Neck pain | 4 | 1 | 0 | 0 | 5 | 20.0 |
| Hypothyroidism | 3 | 2 | 0 | 0 | 5 | 20.0 |
| Proteinuria | 0 | 3 | 2 | 0 | 5 | 20.0 |
| Dry skin | 4 | 1 | 0 | 0 | 5 | 20.0 |
| Arthralgia | 3 | 1 | 0 | 0 | 4 | 16.0 |
| Elevated bilirubin | 0 | 4 | 0 | 0 | 4 | 16.0 |
| Muscular contractures | 4 | 0 | 0 | 0 | 4 | 16.0 |
| Hair modified color | 4 | 0 | 0 | 0 | 4 | 16.0 |
| Epistaxis | 4 | 0 | 0 | 0 | 4 | 16.0 |
| Hemorrhoids | 3 | 1 | 0 | 0 | 4 | 16.0 |
| Microangiopathy | 0 | 0 | 4 | 0 | 4 | 16.0 |
| Paresthesia | 4 | 0 | 0 | 0 | 4 | 16.0 |
| Stomatitis | 2 | 2 | 0 | 0 | 4 | 16.0 |
| Hand & foot syndrome | 3 | 0 | 1 | 0 | 4 | 16.0 |
| Mucositis | 3 | 1 | 0 | 0 | 4 | 16.0 |
| Elevated AST | 2 | 1 | 0 | 0 | 3 | 12.0 |
| Back pain | 2 | 1 | 0 | 0 | 3 | 12.0 |
| Musculoskeletal pain | 2 | 1 | 0 | 0 | 3 | 12.0 |
| Thoracic musculoskeletal pain | 0 | 1 | 2 | 0 | 3 | 12.0 |
| Dyspnea | 3 | 0 | 0 | 0 | 3 | 12.0 |
| Urinary tract infection | 0 | 3 | 0 | 0 | 3 | 12.0 |
| Neutropenia | 0 | 3 | 0 | 0 | 3 | 12.0 |