Table 8.
Known genes interacting with heat stress
| Gene | BTA | Position | Traits | Description | ||
|---|---|---|---|---|---|---|
| Fat | Milk | Protein | ||||
| YBEY | 1 | 147,710,807 | ✓ | The translation-associated heat shock genes, playing key roles in the heat-shock response of E. coli under heat shock stress [41, 42]. | ||
| Unknown | 2 | 112,901,035 | ✓ | ✓ | ✓ | In association with the gene SERPINE2, which had been proven to impact the sweating rate of dairy cattle [43] |
| SOCS2 | 5 | 23,522,032 | ✓ | Suppressor of cytokine signalling 2, might be responsible for heat stress abatement during the dry period of dairy cattle [56]. | ||
| HSF1 | 14 | 1,806,291 | ✓ | Genes involved in the bovine heat stress response [45, 57]. | ||
| DYRK3 | 16 | 4,288,402 | ✓ | The dual specificity tyrosine-phosphorylation-regulated kinase 3, impacting Respiration rate (breaths per minute) in dairy cattle [43] | ||
| NFAT5 | 18 | 36,897,740 | ✓ | Nuclear factor of activated T cells, simulating transcription of Heat shock protein 70 [58]. | ||
| SSTR1 | 21 | 48,804,372 | ✓ | Somatostatin receptor 1, playing a role in heat stress sensing or communicating stress status between cells [59]. | ||
| CACNA2D3 | 22 | 46,612,204 | ✓ | Methylation of the Calcium Channel-Related Gene, showing impaired behavioural heat pain sensitivity in mice and human studies [60]. | ||
| MED17 | 29 | 1,021,424 | ✓ | The mediator mutant yeast, which was temperature-sensitive [61]. | ||
| ME3 | 29 | 8,968,989 | ✓ | Malic Enzyme 3, conferring heat-stable resistance to root-knot nematodes in plants [62]. | ||
| MACROD1 | 29 | 43,097,815 | ✓ | Heat shock protein 90 kDa alpha (cytosolic), class A member 1, which might be in association with PAR (had been proved to function heat shock response) [63, 64]. | ||
| STIP1 | 29 | 43,108,351 | ✓ | ✓ | Stress inducible protein 1, was homologous to the human heat shock cognate protein 70 (hsc70)/heat shock protein 90 (hsp90) [47]. | |
| GSTP1 | 29 | 46,094,664 | ✓ | Glutathione S-transferase Pi, which was reported to play a positive role under heat stress in controlling cellular toxicants and to alleviate the destructive effect on cattle [65]. | ||
| ATG2A | 29 | 43,751,656 | ✓ | Autophagy Related 2 Homolog A, which had been referred to as the Heat Stress-repressed target genes by Niskanen et al., 2015 [66]. | ||
All the listed genes are identified by HyB_BR using the variants with the largest variances