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. 2017 Aug 15;9:84. doi: 10.1186/s13148-017-0383-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — A model with four cfnucleosome biomarkers discriminates IPF vs healthy patients. ROC curve for the discrimination of untreated IPF vs healthy subjects. The AUC for a model of four cfnucleosome biomarkers (HMGB1, 5mC, H3K9Ac, H3K27Ac) reached 0.928 (p < 0.001) with a sensitivity of 91% at 80% specificity