Table 1.
Subject characteristics
| Healthy subjects n = 27 |
Untreated IPF n = 23 |
Treated IPF n = 27 |
|
|---|---|---|---|
| Age, years | 60(9) | 72(11)** | 68(9)* |
| Gender (M/F) | 14/13 | 20/3 | 19/8 |
| Height, cm | 170(9) | 171(10) | 170(9) |
| Weight, kg | 74(12) | 76(15) | 78(10) |
| BMI, kg/m2 | 26(3) | 26(4) | 27(3) |
| Smokers (NS/FS/S) | 6/17/4 | 6/13/4 | 7/20/0 |
| FEV1 post-BD, %pred. | 104(14) | 75(14)*** | 67(13)*** |
| FVC post-BD, %pred. | 112(20) | 74(14)*** | 66(16)*** |
| FEV1/FVC post-BD, % | 78(5) | 78(11) | 80(6) |
| TLC, %pred. | nd | 70(13) | 68(15) |
| RV, %pred. | nd | 71(32) | 82(27) |
| DLCO, %pred. | nd | 39(13) | 38(13) |
| KCO, %pred. | nd | 62(13) | 70(20) |
| ICS (yes/no) | 0/27 | 1/22 | 0/27 |
| OCS (yes/no) | 0/27 | 0/23 | 0/27 |
| Treatment with pirfenidone/nintedanib | nd | nd | 18/9 |
Data are expressed as mean (SD)
nd not determined, NS non-smoker, FS former smoker, S smoker, FEV1 forced expired volume in one second, FVC forced vital capacity, TLC total lung capacity, DLCO diffusion lung capacity for CO, KCO DLCO/alveolar ventilation, ICS inhaled corticosteroids, OCS oral corticosteroids
*p < 0.05, **p < 0.001, ***p < 0.0001 compared to healthy subjects