Table 2.
Single cfnucleosome AUC and sensitivity at 80% specificity
| Nu.Q™ assay | IPF (untreated) vs healthy | |
|---|---|---|
| AUC | % sensitivity at 80% specificity | |
| mH2A1.1 | 0.85 | 86 |
| 5mC | 0.83 | 78 |
| HMGB1 | 0.81 | 74 |
| H3K27Ac | 0.79 | 74 |
| H3K9Ac | 0.77 | 61 |
| H4K20Me3 | 0.70 | 50 |
| pH2AX | 0.66 | 39 |
| H4Pan(Ac) | 0.57 | 13 |
| H3K4Me2 | 0.57 | 14 |
| H3K9Me3 | 0.54 | 13 |
cfnucleosome features between healthy subject (n = 27) and untreated (n = 23) idiopathic pulmonary fibrosis patients. The receiver operator characteristic (ROC) curve analysis is calculated at 80% specificity. All serum nucleosome modifications were analyzed by ELISA Nu.Q™ assays
AUC area under the curve