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. Author manuscript; available in PMC: 2018 Jul 14.
Published in final edited form as: Pharmacology. 2017 Jul 14;100(3-4):188–193. doi: 10.1159/000478732

Fig. 1.

Fig. 1

Effect of aging and GPER on endothelium-dependent relaxation to acetylcholine in renal arteries. The role of Nox-derived oxidative stress was assessed using the Nox1/2-inhibitor gp91ds-tat (tat, 3 μmol/L) in wild-type and Gper−/− mice at 4 (young) or 24 (aged) months of age. Responses are expressed as percent of precontraction to phenylephrine (PE). Insets: area under the curve (AUC) of the concentration-response curves given as arbitrary units. Data (n=4–5 per group) are means±SEM. **p<0.01, ***p<0.001 vs. young; ††p<0.01 vs. untreated control (CTL); ‡‡p<0.01 vs. wild-type.