Table 1.
Clinical and electrographic characteristics of patients with LGI1-antibodies. LGI1-antibody level (end-point dilution shown; * = additional CASPR2-antibody positivity), A = arm, F = face, L = leg involvement during FBDS; a = lateralisation (R right; L left; BL bilateral); b = distribution (CT centrotemporal; Temp temporal; FT Frontotemporal; FC Frontocentral; FCP Fronto-Centro-Parietal);c = two patients had sensory aura preceding some motor events; p = patients who underwent prolonged recordings.
| FBDS |
Motor/ subclinical seizures |
Sensory seizures |
Frequency (motor & sensory seizures) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Age (years) | Sex | LGI1- antibody level | Number per hour | Arm, face and/or leg involved | Ictal EEG changes | Semiologya | Ictal EEGa,b | Semiology | Ictal EEGa,b | Number per hour |
| 71 | M | 540 | Not captured | N | Clonic L arm and neck (3/4), automatisms (1/4) | L CT (n = 4) | – | – | 1.4 | |
| 67 | M | 14580 | 5.4 | AF,AFL and L | N | – | – | Fear, tingling cold sensation, and flushing (n = 1) | Nil | 0.6 |
| 61p | M | 4860 | 4.2 | A | N | – | – | – | – | |
| 78p | M | 4860 | 0.4 | AF | N | Posturing,lip smacking, blinking and tachycardia (3/3) | R Temp (n = 3) | 0.1 | ||
| 92p | M | 14580 | 0.1 | AFL | Y | – | – | – | – | – |
| 63 | M | 1620 | Not captured | N | – | – | Warm surge (n = 1) | Nil | 2 | |
| 69p | M | 14580 | 0.2 | AF | N | – | – | – | – | – |
| 56c,p | M | 14580 | 0.1 | AF | N | L shoulder twitching, throat clearing, lip smacking, L hand posturing (1/7) | L FT (n = 1); FC (R 2/3, L 1/3), R Temp (n = 3) | Tingling (n = 2) | BL FC (1/2) | 0.1 |
| 68 | M | 1620 | 2.4 | AF and F | N | – | – | – | – | – |
| 76p | M | 1620 | 0.2 | AFL, and F | N | Pain R face (n = 1) | Nil | 0.1 | ||
| 64 | F | 4860 | 4.2 | AFL, AF and L | Y | Arousal (1/6), no clinical change in 5/6 | R FT (n = 6) | – | – | 1.5 |
| 63 | F | 4860* | 9.8 | AFL | Y | Oral automatisms (1/1) | R Temp (n = 1) | – | – | 0.1 |
| 69c,p | M | 4860* | 0.2 | AFL, AF and LL | N | Nocturnal arousals (3/6), no clinical change (2/6); L hand twitching (n = 1/6) | L FT (n = 5) | Cold sensation (n = 9); lip quivering (n = 3);) | L Temp (1/9) and L FCP (1/9) | 0.7 |
| 66p | M | 4860* | 0.4 | AFL | N | – | – | – | – | 0.1 |
| 64 | F | 14580 | 5.4 | AF | N | Vocalisations, unresponsive, automatisms, post ictal confusion (8/8); L Head version (n = 3/8) | L Temp (n = 6) and R FT (n = 2) | Body shuddering and goosebumps (n = 2) | Nil | 0.1 |
| 53 | M | 4860 | 0.1 | AF | N | – | – | Body shuddering (n = 3) | Nil | 0.1 |