Skip to main content
. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Aquat Toxicol. 2017 Jun 21;190:1–10. doi: 10.1016/j.aquatox.2017.06.019

Figure 6.

Figure 6

Synthetic TR antagonist NH-3 inhibits TH signaling. A-C. Morphological changes induced by 5 nM T3 are inhibited by NH-3. Boxes represent the 25th–75th percentile values, and the line is at the median; whiskers show maximum and minimum values (n = 15). Slashed boxes indicate samples with T3. D. Inhibition of T3-induced cellular proliferation in the RHR by NH-3. E. Inhibition of T3-induced activation of the TRE-Luc reporter in tadpole heads by NH-3. Bars represent the mean with standard error (n = 15). Significantly different from vehicle control at *, p < 0.05; ****, p<0.0001 as determined by 1-way ANOVA with Sidak’s multiple comparison test (MCT).