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. Author manuscript; available in PMC: 2017 Aug 16.
Published in final edited form as: J Neurol Neuromedicine. 2017 Jul 10;2(7):11–15. doi: 10.29245/2572.942x/2017/7.1134

Figure 1.

Figure 1

Schematic overview of iPSC-based disease modelling for cerebellar ataxias. Somatic cells from patients are reprogrammed into iPSCs by the introduction of pluripotency factors. These iPSCs can then be differentiated into disease-relevant cell types in either 2D- or 3D-format, following protocols that mimic cerebellar developmental cues in vitro. Cell culture models may then be used as a platform for the investigation of disease phenotypes, as well as for drug screening, with the ultimate goal of delivering effective therapies to patients.