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. 2017 Jun 15;31(12):1202–1211. doi: 10.1101/gad.302323.117

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© 2017 Zhang et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — RORα and RORγ redundantly regulate clock and metabolic genes. (A–D) Gene expression of Rora and Rorc (A,B) and clock genes Bmal1 and Npas2 (C,D) in ROR single-knockout or double-knockout livers at ZT22. Data are expressed as mean ± SEM (*) P < 0.05, Student's t-test. n = 4–5 per group. (E) Heat map of the ROR single-knockout and double-knockout liver microarray analysis at ZT22. The color bar indicates the log₂ fold change ratio of Cre/GFP. The cutoff used here was fold change >1.3 with a 15% false discovery rate. (F) Gene ontology analysis of the down-regulated genes and up-regulated genes in the ROR LDKO livers at ZT22.