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. 2017 Jun 15;31(12):1202–1211. doi: 10.1101/gad.302323.117

Figure 6.

Figure 6.

Increased expression of lipogenic genes in ROR LDKO livers occurs in the fed, but not fasted, state. (A) Study design and schedule for fasted and feeding study groups. (B–H) mRNA expression of RORs (B,C) and lipid metabolic genes, including Elovl6 (D), Fasn (E), Scd1 (F), Spot14 (G), and Acly (H), at ZT22, normalized to Arbp, as measured by RT-qPCR. Data are expressed as mean ± SEM. (*) P < 0.05, Student's t-test. n = 3–5 per group. (I) mRNA expression levels of Insig2 in the control and ROR LDKO mouse livers under feeding or fasting condition. Data are expressed as mean ± SEM. (*) P < 0.05, Student's t-test. n = 3–5 per group. (J) Hepatic triglyceride measurement of the livers from the fed and fasted control mice and ROR mutant mice fed a high-fat diet for 6 wk. (mg/g) Milligrams of triglycerides per gram of liver weight. Data are expressed as mean ± SEM. (*) P < 0.05, Student's t-test. n = 3–5 per group.