Fig 3. Involvement of Nrf2 signaling pathway in the cytoprotective actions of ginsenosides Rb1 and Rg1.
(A) Degree of activation of Nrf2 factor in nuclear extracts of SH-SY5Y cells. (B) Effects of ginsenosides on Nrf2 protein levels in cytoplasm and (C) in nucleus; representative blots from purified cytoplasmic and nuclear fractions. Cells were pre-treated with ginsenosides for 24 h with/without later exposure to rotenone 50 μM for other 24 h. Data are expressed in percentage relative to untreated control cells. Means ± SD, * p < 0.05 Vs control, # p < 0.05 Vs rotenone-treated cells.