Table 1. Genotypes for top GWAS SNP and LINE-1 insertion in Swedish Vallhunds from the UK and Finland.
Table 1a UK dogs (24 cases and 97 controls) | ||||
Retinopathy status | ||||
SNP_BICF2G630207991 genotypea | Case n (freq.) | Control n (freq.) | Total | |
T/T | 3 (0.13) | 25 (0.26) | 28 | |
T/C | 6 (0.25) | 67 (0.69) | 73 | |
C/C | 15 (0.63) | 5 (0.05) | 20 | P-value: 4.7 x 10−9 |
LINE-1 insertion genotype | ||||
Wildtype | 3 (0.13) | 28 (0.29) | 31 | |
Heterozygote | 6 (0.25) | 67 (0.69) | 73 | |
LINE-1 ins | 15 (0.63) | 2 (0.02) | 17 | P-value 6.0 x 10−11 |
Table 1b Finnish dogs (49 cases and 89 controls) | ||||
Retinopathy status | ||||
SNP_BICF2G630207991 genotypea | Case n (freq.) | Control n (freq.) | Total | |
T/T | 0 (0.00) | 26 (0.29) | 26 | |
T/C | 7 (0.14) | 51 (0.57) | 58 | |
C/C | 42 (0.86) | 12 (0.13) | 54 | P-value 1.3 x 10−17 |
LINE-1 insertion genotype | ||||
Wildtype | 0 (0.00) | 28 (0.31) | 28 | |
Heterozygote | 7 (0.14) | 51 (0.57) | 58 | |
LINE-1 ins | 42 (0.86) | 10 (0.11) | 52 | P-value 4.3 x 10−19 |
a For SNP_BICF2G630207991 the risk allele is C