Table S2.

Estimates of inbreeding depression for 25 quantitative traits measured in the UK Biobank

		FUNI		FHOM		$F_{\mathrm{ROH}}^{(1)}$		$F_{\mathrm{ROH}}^{(2)}$
Traits	N	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value
PEF	117,575	−4.1 (0.6)	4.6 $\mathrm{\times }$ 10−11	−2.7 (0.5)	2.1 $\mathrm{\times }$ 10−8	−7.6 (1.4)	1.3 $\mathrm{\times }$ 10−7	−8.5 (1.5)	3.9 $\mathrm{\times }$ 10−8
AA	43,175	5.2 (1.0)	5.5 $\mathrm{\times }$ 10−7	3.2 (0.8)	7.5 $\mathrm{\times }$ 10−5	9.4 (2.4)	1.1 $\mathrm{\times }$ 10−4	11 (2.6)	1.3 $\mathrm{\times }$ 10−5
WHR	140,295	2.3 (0.5)	1.1 $\mathrm{\times }$ 10−5	1.8 (0.4)	3.2 $\mathrm{\times }$ 10−5	2.7 (1.2)	0.02	4.5 (1.3)	5.5 $\mathrm{\times }$ 10−4
HGS	139,623	−2.4 (0.5)	1.4 $\mathrm{\times }$ 10−5	−1.6 (0.4)	1.5 $\mathrm{\times }$ 10−4	−3.8 (1.2)	1.8 $\mathrm{\times }$ 10−3	−4.3 (1.3)	1.1 $\mathrm{\times }$ 10−3
FIS	45,043	−3.9 (1.0)	5.4 $\mathrm{\times }$ 10−5	−2 (0.8)	8.2 $\times$ 10−3	−7.9 (2.2)	3.9 $\mathrm{\times }$ 10−4	−7.9 (2.4)	9 $\mathrm{\times }$ 10−4
MTCIM	138,902	1.9 (0.5)	3.7 $\mathrm{\times }$ 10−4	1.3 (0.4)	2.4 $\times$ 10−3	3.7 (1.2)	2.5 $\times$ 10−3	3.6 (1.3)	6.2 $\times$ 10−3
Height	140,302	−1.9 (0.5)	4.8 $\mathrm{\times }$ 10−4	−1.1 (0.4)	0.01	−2.7 (1.2)	0.03	−3.5 (1.3)	7.3 $\times$ 10−3
VA	29,616	4 (1.2)	7.4 $\mathrm{\times }$ 10−4	2 (0.9)	0.04	7.7 (2.7)	4.9 $\times$ 10−3	7.9 (2.9)	7.3 $\times$ 10−3
NCF	51,494	−3.1 (1.0)	1.3 $\mathrm{\times }$ 10−3	−2.4 (0.7)	1.4 $\mathrm{\times }$ 10−3	−5.4 (2.2)	0.01	−7.7 (2.4)	1.3 $\mathrm{\times }$ 10−3
WC	140,233	1.4 (0.5)	7.2 $\times$ 10−3	0.91 (0.4)	0.03	1.9 (1.2)	0.12	2.7 (1.3)	0.04
BFat	138,055	1.1 (0.4)	0.05	0.71 (0.4)	0.09	1.6 (1.2)	0.19	1.9 (1.3)	0.14
HR	130,694	1.1 (0.6)	0.05	1.2 (0.4)	5.7 $\times$ 10−3	2.6 (1.3)	0.04	3.2 (1.4)	0.02
MNDR	145,75	−3.4 (1.8)	0.06	−2.7 (1.4)	0.06	−6.7 (4.3)	0.19	−8.3 (4.5)	0.07
A-Mena	72,196	1.3 (0.8)	0.08	0.29 (0.6)	0.63	1.4 (1.7)	0.42	1.9 (1.9)	0.3
BMI	139,686	0.94 (0.5)	0.08	0.54 (0.4)	0.21	0.86 (1.2)	0.48	1.3 (1.3)	0.3
BMR	138,047	−0.83 (0.5)	0.12	−0.61 (0.4)	0.16	−2.3 (1.2)	0.05	−2.5 (1.3)	0.05
A-Edu	95,540	−0.6 (0.6)	0.34	−0.36 (0.5)	0.48	0.19 (1.4)	0.89	−0.07 (1.5)	0.96
NLB	59,943	0.8 (0.9)	0.36	0.26 (0.7)	0.71	1.1 (2)	0.57	0.77 (2.1)	0.72
NIM	138,543	−0.45 (0.5)	0.41	−0.79 (0.4)	0.07	−2.9 (1.2)	0.02	−3.1 (1.3)	0.02
A-Meno	42,782	−0.82 (1.0)	0.43	−0.2 (0.9)	0.82	−1.8 (2.5)	0.46	−2 (2.7)	0.44
SBP	130,787	0.32 (0.6)	0.57	0.01 (0.4)	0.99	0.24 (1.3)	0.85	0.79 (1.4)	0.56
BMD	80,698	−0.31 (0.7)	0.65	−0.26 (0.5)	0.64	0.69 (1.5)	0.65	0.08 (1.6)	0.96
DBP	130,831	0.17 (0.56)	0.75	−0.21 (0.4)	0.63	0.8 (1.3)	0.52	1.1 (1.4)	0.39
HC	139,694	0.11 (0.54)	0.83	−0.1 (0.4)	0.81	0.5 (1.2)	0.68	0.17 (1.3)	0.89
Weight	139,916	−0.07 (0.5)	0.89	−0.096 (0.4)	0.82	−0.71 (1.2)	0.56	−0.68 (1.3)	0.59

AA, auditory acuity measured as the speech reception threshold; A-Edu, age when completed full education; A-mena, age at menarche; A-Meno, age at menopause; BFat, body fat percentage; BMD, bone mineral density; BMI, body mass index; BMR, basal metabolic rate; DBP, diastolic blood pressure; FIS, fluid intelligence score; HC, hip circumference and weight; HGS, hand grip strength; HR, heart pulse rate; MNDR, maximum number of digits remembered; MTCIM, mean time to correctly identify matches during cognitive test; NCF, number of children fathered; NIM, number of incorrect matches during cognitive test; NLB, number of live births; PEF, peak expiratory flow; SBP, systolic blood pressure; VA, visual acuity in log MAR scale; WC, waist circumference; WHR, ratio of waist circumference over hip circumference. Effect sizes and SEs are expressed in phenotypic SD. N: sample size in the analysis. Other abbreviations are defined in Fig. S2. P values <0.05/25 = 0.002 are highlighted in boldface type.