Table 1.

Statistically significant estimates of inbreeding depression for eight quantitative traits measured in the UK Biobank

		${\text{F}}_{\text{UNI}}$			${\text{F}}_{\text{UNI}}(\text{LDMS})$
Traits	N	Estimate	SE	P value	Estimate	SE	P value	PHET
PEF	117,575 (103,781)	−4.1 (−4.1)	0.62 (0.74)	4.57 $\times {10}^{-11}$ (3.48 $\times {10}^{-8}$)	−4.12 (−4.19)	0.69 (0.84)	2.25 $\times {10}^{-9}$ (6.35 $\times {10}^{-7}$)	0.941 (0.81)
AA, speech reception threshold	43,175 (38,449)	5.23 (4.44)	1.04 (1.26)	5.55 $\times {10}^{-7}$ (4.45 $\times {10}^{-4}$)	5.34 (4.39)	1.16 (1.45)	4.6 $\times {10}^{-6}$ (2.51 $\times {10}^{-3}$)	0.828 (0.94)
FIS	45,043 (40,089)	−3.9 (−3.14)	0.97 (1.23)	5.36 $\times {10}^{-5}$ (1.08 $\times {10}^{-2}$)	−4.72 (−4.32)	1.06 (1.42)	8.52 $\times {10}^{-6}$ (2.25 $\times {10}^{-3}$)	0.061 (0.07)
HGS, average of left and right hands	139,623 (122,950)	−2.36 (−2.72)	0.54 (0.68)	1.38 $\times {10}^{-5}$ (5.79 $\times {10}^{-5}$)	−2.43 (−3.31)	0.6 (0.76)	4.64 $\times {10}^{-5}$ (1.51 $\times {10}^{-5}$)	0.771 (0.1)
NCF	51,494 (45,483)	−3.09 (−3.69)	0.96 (1.16)	1.27 $\times {10}^{-3}$ (1.44 $\times {10}^{-3}$)	−4.01 (−4.58)	1.07 (1.32)	1.79 $\times {10}^{-4}$ (5.17 $\times {10}^{-4}$)	0.039 (0.14)
MTCIM	138,902 (122,334)	1.94 (1.7)	0.54 (0.68)	3.66 $\times {10}^{-4}$ (1.21 $\times {10}^{-2}$)	2.05 (2.1)	0.6 (0.77)	6.14 $\times {10}^{-4}$ (6.24 $\times {10}^{-3}$)	0.647 (0.26)
WHR	140,295 (123,540)	2.35 (3.03)	0.53 (0.67)	1.12 $\times {10}^{-5}$ (6.18 $\times {10}^{-6}$)	1.97 (2.89)	0.6 (0.76)	7.85 $\times {10}^{-4}$ (1.37 $\times {10}^{-4}$)	0.121 (0.69)
VA, log MAR scale	29,616 (26,596)	4.04 (5.77)	1.20 (1.51)	7.42 $\times {10}^{-4}$ (1.37 $\times {10}^{-4}$)	4.39 (6.68)	1.32 (1.73)	9.04 $\times {10}^{-4}$ (1.14 $\times {10}^{-4}$)	0.518 (0.26)

Effect sizes and standard errors are expressed in phenotypic SD of the trait. Results presented in parentheses were obtained after removing 16,781 related individuals and 19 extreme cases of inbreeding (F_UNI >0.15). N: sample size in the analysis. P_HET is the P value from the LDMS heterogeneity test comparing nonstratified and LDMS-stratified estimates.