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Conjugation of diacyl lipid to oligonucleotides increases circulation half-life and reduces renal clearance. (A) Cy5-labeled siRNA-L2 and siRNA fluorescence in the blood measured in real time intravitally by confocal microscopy after i.v. injection of CD1 mice. (B) Representative images of fluorescence in mouse blood vessels over time. (C) Organ biodistribution of siRNA and siRNA-L2 at 20 min after i.v. injection. n = 3, SE shown; ***P < 0.001.
