Skip to main content
. 2017 Jul 24;114(32):E6490–E6497. doi: 10.1073/pnas.1621240114

Table 1.

Key pharmacokinetics parameters for siRNA-L2 vs. siRNA

Parameter siRNA siRNA-L2 P value
t1/2, circulation, min 2.3 ± 0.2 13.1 ± 1.6 0.0023
AUCcirc, 0-∞, fluor. intensity × min 5,500 ± 800 47,300 ± 6,700 0.0034
Fraction kidney radiance 0.790 ± 0.018 0.503 ± 0.014 <0.0001

AUC, area under curve.