Table 2.

Key pharmacokinetic parameter comparisons of siRNA-L₂ vs. jetPEI NPs

Parameter	jetPEI NPs	siRNA-L2(1 mg/kg dose)	siRNA-L2(10 mg/kg dose)	P valueL2 (1 mg/kg dose)	P valueL2 (10 mg/kg dose)
AUCtumor, 0.5–48 h, radiance × h	1.48 × 1010	3.61 × 1010	2.90 × 1011
Liver:tumor ratio24 h, orthotopic	2.6 ± 0.2	15.4 ± 5.0	40.7 ± 5.2	0.1117	0.0007
Liver:tumor ratio24 h, PDX	1.5 ± 0.4	7.8 ± 1.8		0.1357
Liver:tumor ratio48 h, orthotopic	2.8 ± 0.2	6.2 ± 2.6	43.1 ± 2.7	0.1739	0.0007
Fold tumor cell uptake, 30 min	7.2 ± 0.6	34.7 ± 4.7	325.2 ± 29.0	0.0001	<0.0001
Fold tumor cell uptake, 24 h	16.7 ± 1.0	31.0 ± 3.6	326.8 ± 16.0	0.0032	<0.0001

AUC, area under curve.