Fig. 2.

Differential effects of propofol in deep and superficial layers. (A and B) Difference in power between layers during induction of anesthesia. (A) Example raw traces observed during LORR from electrodes located in layers 2/3 (blue), 5 (green), and 6 (red). (B) Baseline-normalized, difference group spectra between layers, at each behavioral event. Shaded area represents 99% confidence intervals. (C and D) Difference in power between layers during emergence from anesthesia. (C) Example raw traces observed during preROM from electrodes located in layers 2/3, 5, and 6. Color code is the same as in A. (D) Baseline-normalized, difference group spectra at each behavioral event. Color code is the same as in B. In A and C, the yellow squares highlight portions of the raw traces where deep layers display bigger amplitude than superficial layers. The shaded area in all group spectra represents 99% confidence intervals, and the horizontal lines mark the frequencies at which power is significantly different from baseline beyond the spectral resolution (3 Hz). Vertical scale: 1,000 $\mu$V. Horizontal scale: 1 s.