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. 2017 Jul 24;114(32):8620–8625. doi: 10.1073/pnas.1700917114

Fig. 3.

Fig. 3.

Car6 selectively promotes induction of IL-12 in macrophages upon innate stimuli. (A) Heatmap of gene expression in Car6+/+ and Car6−/− PMs with or without LM stimulation for 8 h. Log10-expression values were calculated from RNA-seq. (B–D) qPCR assay of Il12b (B), Il12a (C), and Il23a (D) expression in the Car6+/+ and Car6−/− PMs after stimulation by LM or LPS for the indicated time. (E) ELISA of IL-12p70 in the supernatants of cells stimulated as in B. Data were shown as mean ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001.