Fig. S3.

Aligned amino acid sequences of the simian HEMO proteins. The characteristic domains are delineated, with the putative proteolytic furin cleavage site (RXKR; black) between the SU and TM subunits, the signal peptide (purple) and the CWLC motif (CXXC; black) in the SU subunit, the ISD (blue), the C6XCC sequence (black), and the transmembrane domain (red) in the TM subunit. Dots indicate amino acid identity, and hyphens indicate codon deletions. Coordinates of the genomic nucleotide sequences used for aminoacid translation are listed in Table S5, except for the nucleotide sequences of gibbon, baboon, langur, spider monkey, and saki monkey, which were determined (SI Methods) and are reported in Dataset S1. Apes names are in black, OWMs names in green, and NWMs names in brown. agm, African green monkey; bab, baboon; col, Angolan black-and-white colobus; cpz, chimpanzee; gib, gibbon; gor, gorilla; hum, human; lan, langur; mac, macaque; mar, marmoset; NWM, New World monkey; oo, orangutan; OWM, Old World monkey; rhi, golden snub-nosed monkey; sak, saki monkey; spi, spider monkey; sqm, squirrel monkey.