Table S3.

List of primers

Primer names	Primer sequences
qRT-PCR
HEMO-F1	5′-ACTATGGGCTCCCTTTCAAACT
HEMO-R1	5′-CATAGGAGGAAGTAGAGTGATT
RPLP0-F	5′-GGCGACCTGGAAGTCCAACTA
RPLP0-R	5′-CCATCAGCACCACAGCCTTC
G6PD-F	5′-TGCAGATGCTGTGTCTGG
G6PD-R	5′-CGTACTGGCCCAGGACC
RACE experiments
HEMO-5′-RACE-R	5′-CCTTGGGAGGTCCTAGTGCTAAGTGC
HEMO-3′-RACE-F	5′-AAGCCACAGGAAGCTAGATTGAGATCAT
HEMO-R2	5′-GCTGTCTACTTCATCTGCTCAT
HEMO-R4	5′-CCGCAGACGTAGACAACGAA
HEMO-F4	5′-TTTCAAATAGGGCAATGAAGG
panMars-5′-RACE-R	5′-CATCTGTCCTCTGGAACATCGCCCAAG
panMars-R2	5′-TCAGTTTCCATATTACCCACTT
panMars-R3	5′-CAAGGAGTGAACTGAAGTGG
panMars-R4	5′-ATTCGTCAGAACAACCCAATAG
Bisulfite experiments
Fragment I
I-F	5′-AGGTAGGTAGTGGATATAGGTG
I-R	5′-AAACCAAAAAACCAAAAAAA
Fragment I nested
I-F2	5′-GTAGTGGATATAGGTGGTT
I-R2	5′-AAACCAAAAAACCAAAAAAAAAAC
Fragment II
II-F	5′-TTTTAATTTAGGATTTTTTTAGT
II-R	5′-ATCTACCCTAAAAAAACAAA
Fragment II nested
II-F2	5′-TTTTTTTTTTGGTTTTTTGG
II-R2	5′-AAAAAACAAAACRCAAACTTATTAC
Amplification of genomic HEMO in primate species
HEMO-Ge-F-Xho	5′-ATACATCTCGAGCATTGTCTGGAGTTTGCTTGT
HEMO-Ge-R-Mlu	5′-ATACATACGCGTGGGTAAGGGTTTACAGATCAG
HEMO-NWM-R-Mlu	5′-ATACATACGCGTACACCTTGGGAGGTCCTAGT
Amplification of promoter fragments
HEMO-(-290)F	5′-(NNN)GTCCTGCCCTCGTCCCGAAG
HEMO-(+1)F	5′-(NNN)CACTTCAGTTCCCGCCGCGA
HEMO-(+57)F	5′-(NNN)GCCAGTTTATCCCTCGGAGTT
HEMO-(472)R	5′-(NNN)CCGCAGACGTAGACAACGAA
Furin site mutation
HEMO-RTKR-F	5′-CACCGCATAGACGCACCAAACGAGACACAGACA
HEMO-RTKR-R	5′-TGTCTGTGTCTCGTTTGGTGCGTCTATGCGGTG