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. 2017 Jul 24;114(32):8568–8573. doi: 10.1073/pnas.1702526114

Fig. 4.

Fig. 4.

Applied EF polarizes and clusters Cav for directional migration. (A) Lipid raft disruption inhibited Cav-1 polarization in EF (n = 26–42, *P < 0.001 vs. 0 V, §P < 0.001 vs. control). (B) EF induced Cav oligomerization (P < 0.05, n = 5). (C) Cav knockdown reduced EF-induced directional migration (n = 11–46, *P < 0.0001 vs. 0 V, §P < 0.003 vs. neg). (D) Functional blocking of integrin suppressed polarized distribution of Cav (n = 14–42, *P < 0.01 vs. 0 V, §P < 0.0001 vs. control). (E) Cav-1 knockdown attenuated raft, RhoA, PI3K, and integrin polarization in response to applied EF (n = 13–107, *P < 0.03 vs. 0 V, §P < 0.02 vs. neg).