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. 2017 Jul 24;114(32):8631–8636. doi: 10.1073/pnas.1708106114

Fig. S3.

Fig. S3.

BACE inhibitor treatment reduces the amount of prefibrillar Aβ in the periphery of plaques. (A) Confocal images of cortical sections from untreated (Top) and NB-360-treated (Bottom) APP23xPS45 mice double-labeled with OC antibody (red) and thioflavin-S (cyan). (B) Quantification of the ratio of OC+ prefibrillar Aβ to thioflavin-S+ plaque cores in the untreated mice (control; n = 4) and treated mice (NB-360; n = 6). There was a highly significant reduction in the amount of prefibrillar Aβ around the plaques after treatment with NB-360 (4.16 ± 0.55 for control vs. 2.22 ± 0.21 for NB-360; two-sample t test, t = 3.8; df = 8; P = 0.0050). **P < 0.01. Error bars represent mean ± SEM.