Fig. S5.

BACE inhibition reduces hypersynchrony of neurons. There was a significantly higher number of correlated Ca²⁺ transients in untreated APP23xPS45 mice (red; n = 64 recording sites in eight mice) relative to WT mice (blue; n = 47 recording sites in five mice), and a strong decrease in abnormal correlation in NB-360–treated APP23xPS45 mice (green; n = 81 recording sites in 10 mice) [F(2,198) = 39.79, P < 0.0001; Tukey's post hoc comparisons: P < 0.0001 for WT vs. control and P < 0.0001 for control vs. NB-360). In the boxplot, the top bar is the maximum observation, the lower bar is the minimum observation. The box extends from the 25th percentile to the 75th percentile, with the middle bar as the median. ****P < 0.0001.