Fig 4. S. aureus biofilm is capable of stimulating the conversion of the CD11b-positive MDSCs into macrophages or M2-macrophgates in vitro.

The isolated CD11b-positive MDSCs were cocultured with elevated amounts (0.2, 0.6 and 2.0 mg/ml) of S. aureus biofilm for 48 hr. The proportions of total macrophages (F4/80⁺) (a) and M2-macrophages (F4/80⁺CD206⁺) (b) in the CD11b-positive cell population were measured by flow cytometry. **p < 0.001.