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. 2017 Jul 27;9(7):1745–1760. doi: 10.18632/aging.101267

Figure 1. ACBPs regulate C. elegans lifespan.

Figure 1

(A) Downregulation of maa-1 promotes longevity. Lifespans of wildtype worms (N2) subjected to control RNAi vs maa-1 dsRNA, P<0.0001. (B) Downregulation of acbp-1 or acbp-3 modestly increases longevity. Lifespans of wild-type worms subjected to control RNAi vs acbp-1 RNAi, P<0.01; and control RNAi vs acbp-3 RNAi, P=0.056. (C-D) Loss-of-function mutations maa-1(ok2033) (C) and maa-1(sv38) (D) prolong lifespan (both P<0.0001). P values were calculated using the log-rank (Mantel-Cox) method. Replicate experiments and details of statistical analyses are shown in Table S1 and S2.