FIG. 1.

Schematic concept of the NANOCI project. Overview (A) and mid-modiolar cross-section through the cochlea with a CI electrode array inserted into the scala tympani (pink, B) at distance from the auditory neuron (green, B–D). By providing structural support, guidance, and attraction cues from an injected, functionalized nanomatrix (blue shaded fill, B–D) and from the modified electrode array surface (white coating of pink electrode array, C and D), a guided growth of the neurite onto the electrode surface is induced where a gapless nerve-CI interface is formed. CI indicates cochlear implants.