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. Author manuscript; available in PMC: 2018 Jun 19.
Published in final edited form as: Dev Cell. 2017 Jun 19;41(6):652–664.e5. doi: 10.1016/j.devcel.2017.05.019

Figure 4. Overexpression of dEDEMs protects against chronic ER proteinopathy in Aβ42 flies.

Figure 4

(A) Neuronal overexpression of dEDEMs suppressed locomotor defects in Aβ42 flies. Mean ± SEM, n = 6, *p < 0.05 by Mann–Whitney U test. (B) Neuronal overexpression of dEDEMs suppressed neurodegeneration in Aβ42 flies. Percentages of vacuole areas (indicated by arrows) in fly cortices are shown. Scale bar: 10 μm. Mean ± SEM, n = 7–12 hemispheres, **p < 0.01 by Student's t-test. (C) dEDEM overexpression suppressed retinal degeneration induced by Aβ42. Eyes of flies expressing Aβ42 alone, co-expressing Aβ42 and the control protein CD8-GFP, or co-expressing Aβ42 and dEDEMs under the control of the eye-specific driver GMR-GAL4 are shown. Scale bar: 100 μm. See also Figure S4 and Table S5.