Effect of Crocus sativus extract (50 mg/kg/day, one month treatment) and crocin (10 mg/kg/day, one month treatment) consumption on the expression of Aβ major transport proteins, Aβ degrading enzymes, and ApoE clearance pathway proteins in the brains of 5XFAD mice. (A) Representative blots and densitometry analysis of LRP1 and P-gp in microvessels isolated from 5XFAD mice brains. (B) Representative blots and densitometry analysis of IDE and NEP in brain homogenates. (C) Representative blots and densitometry analysis of ABCA1, ApoE and PPAR-γ in brain homogenates. Data are presented as mean ± SEM of six mice in each group (*P < 0.05, **P < 0.01, ***P < 0.001 compared to control group).