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Pseudoprogression in the setting of no measurable tumor burden at baseline. A 66-year-old male with advanced melanoma treated with pembrolizumab. A. The baseline scan showed no measurable tumor burden and subcentimeter, non-measurable brain metastasis. B. A follow-up scan at 1.5 months of therapy showed a new subcutaneous nodule (arrow). C. On a subsequent follow-up scan at 3.5 months of therapy, the nodule has significantly decreased in size (arrow).
