Skip to main content
. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: Clin Cancer Res. 2017 Apr 26;23(16):4680–4692. doi: 10.1158/1078-0432.CCR-16-3029

Figure 2.

Figure 2

A, Hierarchical clustering of single agent effects on melanoma cell viability across ten patient biopsies. B, Excerpts from hierarchical clustering of combination drug effects on melanoma cell viability across ten patient biopsies, showing significant cytotoxic (top) and pro-proliferative/anti-apoptotic (bottom) combinations. C, (Top) Binned median and minimum effects of each combination on the biopsies; while median effects of each combination were clustered at 100% control melanoma cell counts, combinations had significant effects in individual biopsies. (Bottom) Cumulative distribution of above histogram, showing a significant percentage of combinations caused strong viability effects in only a small subset of biopsies.