Table 2.

Grade 3 and 4 AEs in three or more patients at least possibly related to study drug, all cycles

AE	80–640 mg/m2/day (n=8)		905 mg/m2/day (n=6)		1280 mg/m2/day (n=8)		1810 mg/m2/day (n=3)		Expanded Cohort (n=4)
	Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4	Grade 3	Grade 4
Hypertriglyceridemia	1	0	0	4	0	2	0	2	0	0
Non-Hematologic, any	2	0	1	4	3	4	0	3	1	3
Hemoglobin reduced	0	0	0	0	1	0	1	0	1	0
Leukocytes reduced	0	0	1	0	0	0	1	0	1	0
Lymphocytes reduced	0	0	0	0	1	1	0	0	1	0
Neutrophils reduced	0	0	1	1	1	1	1	0	0	0
Platelets reduced	0	0	0	0	3	1	0	1	0	3
Hematologic, any	0	0	1	1	3	3	0	1	1	3