Table 2.
Baseline Patient Demographic and Clinical Characteristics for Transcriptome Profiling*
| Control Group n=15 | Treatment Group n=10 | p | |||
|---|---|---|---|---|---|
| Age Mean (MIN, MAX) | 57 (43,70) | 57.3 (46, 70) | .93 | ||
| BMI Mean (MIN, MAX) | 25.1 (20.3, 32.0) | 26.4 (19.4, 34.5) | .48 | ||
| Weight Mean (MIN, MAX) | 66.1 (52, 86) | 67.7 (50, 94) | .76 | ||
| Smoking – Present | NO YES (<5 cigarette per day) YES (>5 cigarette per day) NA |
13 1 0 1 |
NO YES (<5 cigarette per day) YES (>5 cigarette per day) NA |
5 2 2 1 |
.08 |
| T Staging | Tis T1 T2 T3 |
2 8 4 1 |
Tis T1 T2 T3 |
0 9 1 0 |
.40 |
| Histological Grade(HG) | HG1 HG2 HG2/3 HG3 DCIS/LCIS |
5 6 1 1 2 |
HG1 HG2 HG2/3 HG3 DCIS/LCIS |
2 6 0 1 1 |
.79 |
| Surgical Resection | Lumpectomy Mastectomy Other a,b,c |
11 1 3 |
Lumpectomy Mastectomy Other |
9 1 0 |
.31 |
| Metastatic Spread | No | 15 | No | 10 | 1 |
| ER Status | Negative Positive |
0 15 |
Negative Positive |
1 9 |
.45 |
| PR Status | Negative Positive |
3 12 |
Negative Positive |
3 7 |
.84 |
| HER2/neu status | Negative NA Positive |
8 3 4 |
Negative NA Positive |
6 0 4 |
.30 |
| Tumor Max. Diameter | 1.8 cm | 1.2 cm | .32 | ||
| Carcinoma | Invasive Non-invasive NA |
12 2 1 |
Invasive Non-invasive NA |
8 1 1 |
.93 |
*
Twenty-five tumors yielded RNA quality assured for sufficient mas
a
Mastectomy + Immediate reconstruction with silicone,
b
Lumpectomy (double- Lt&Rt),
c
Lumpectomy (+Intraoperative radiation)
NA - not available;
DCIS – Ductal Carcinoma In Situ;
LCIS – Lobular Carcinoma In Situ