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. 2017 Aug 15;10:262. doi: 10.3389/fnmol.2017.00262

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Copyright © 2017 Wang, Qin and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Roles of OTR-associated signals in Gβγ subunit-modulated expressions of GFAP and phosphorylated extracellular signal-regulated protein kinase (pERK) 1/2. (A) Confocal images (left to right) show staining for nuclei, GFAP, pERK 1/2, NPs and their merges. From top to the bottom, images were acquired in control, mSIRK (0.5 μM, 30 min) and mSIRK following 30 min pretreatment with OT, KT5720 (10 μM), PD98059 (20 μM), or U73122 (10 μM), respectively. (B) Summary graphs of GFAP expression in whole field view, the diameter, or length of GFAP filaments relative to mSIRK alone. (C) Summary graphs of pERK 1/2 under different conditions. Note that, *P < 0.05 compared to the control; ^†P < 0.05 and ^††P < 0.01 compared with mSIRK alone. Other annotations refer to Figures 1, 3.