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. 2017 Aug 15;11:15. doi: 10.3389/fnint.2017.00015

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Copyright © 2017 Härtig, Mages, Aleithe, Nitzsche, Altmann, Barthel, Krueger and Michalski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Concomitantly up-regulated collagen IV (Coll IV)-immunoreactivity and decomposed perineuronal nets (PNs) in a mouse 1 day after ischemia onset. Strong Cy3-immunolabeling of Coll IV (red) indicates ischemia-affected regions with a reduced lectin-histochemical Wisteria floribunda agglutinin (WFA)-staining (green) in coronal sections from the forebrain comprising striatum and somatosensory cortex (A), as well as the auditory and visual cortex, the caudal hippocampus and the pontine gray matter (B) revealed by a Keyence microscope. Scale bars = 1 mm.