FIGURE 4.

NAcSh D1MSN LTD is attenuated by pharmacological inhibition of ALK. (A) Data points are group means ( ± SEM) for normalized (% baseline) EPSC amplitudes averaged in 2-min bins; vehicle (0 nM: n = 6 cells, six mice; 5 nM TAE684: n = 4 cells, three mice; 25 nM TAE684: n = 4 cells, three mice). In the vehicle group alone, evoked EPSC amplitudes during the 40–50 min “post-pairing” period were significantly reduced relative to baseline. ^##p = 0.0003, post-pairing vs. baseline period (simple effect of pairing in vehicle group). (B) Bars show group means ( ± SEM) for normalized EPSC amplitudes averaged over the entire 10-min post-pairing period. 25 nM TAE684 was significantly different from 0 nM (^∗p = 0.02), while 5 nM TAE684 was not different from either concentration (Bonferroni post hoc comparisons). (C) Representative traces of evoked EPSCs during the baseline and post-pairing periods.