Fig. 2.

Spatial heterogeneity in baseline and treated patients. In the upper panel of a the number of unshared copy number aberrations between paired iliac crest and fine needle aspirates (Δ CNA, > 1 Mb) is shown. In the lower panel of a heterogeneity involving the initiating events hyperdiploidy and recurrent IgH translocations as well as commonly used prognostic markers is presented with light and dark red indicating shared and unshared events, respectively. The total number of non-silent mutations is presented in b. c Proportion of clonal unshared (cancer clonal fraction (CCF) ≥ 0.8; dark blue), subclonal unshared (CCF < 0.8; cornflower blue) and shared-diff (green) non-silent mutations. In d, non-silent mutations and deletions affecting the most frequently mutated genes in our set and other recurrently mutated genes in multiple myeloma are shown. Dark blue and cornflower blue denote clonal and subclonal unshared mutations, green shared-diff mutations, red deletions and black bi-allelic events. Light colors or crossed boxes indicate shared events